Metabolism of N-acylethanolamine phospholipids by a mammalian phosphodiesterase of the phospholipase D type.

Abstract

Rat heart contains a membrane-bound phosphodiesterase of the phospholipase D type which catalyzes the hydrolysis of 1,2-diacyl-sn-glycero-3-phospho(N-acyl)ethanolamine to N-acylethanolamine and phosphatidic acid. The enzyme also hydrolyzes the corresponding alkenylacylglycerophospho(N-acyl)ethanolamine and N-acylethanolamine lysophospholipids but not… (More)

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