Metabolism of N-acetylbenzidine and initiation of bladder cancer.

@article{Zenser2002MetabolismON,
  title={Metabolism of N-acetylbenzidine and initiation of bladder cancer.},
  author={T. Zenser and V. Lakshmi and F. Hsu and B. Davis},
  journal={Mutation research},
  year={2002},
  volume={506-507},
  pages={
          29-40
        }
}
A 100-fold increased incidence of bladder cancer is observed with workers exposed to high levels of benzidine (BZ). This review evaluates the overall metabolism of BZ to determine pathways involved in initiation of carcinogenesis. Enzymatic and liver slice incubations demonstrated N-acetylation and N-glucuronidation of BZ and N-acetylbenzidine (ABZ). With rat, N,N'-diacetylbenzidine (DABZ) is the major slice metabolite. With human, ABZ is the major metabolite along with N-glucuronides… Expand
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