Metabolism of Monoamine Oxidase Inhibitors

  title={Metabolism of Monoamine Oxidase Inhibitors},
  author={G. Baker and L. Urichuk and K. F. McKenna and S. H. Kennedy},
  journal={Cellular and Molecular Neurobiology},
  • G. Baker, L. Urichuk, +1 author S. H. Kennedy
  • Published 2004
  • Chemistry, Medicine
  • Cellular and Molecular Neurobiology
  • Abstract1. The principal routes of metabolism of the following monoamine oxidase inhibitors (MAOIs) are described: phenelzine, tranylcypromine, pargyline, deprenyl, moclobemide, and brofaromine.2. Acetylation of phenelzine appears to be a minor metabolic pathway. Phenelzine is a substrate as well as an inhibitor of MAO, and major identified metabolites of phenelzine include phenylacetic acid and p-hydroxyphenylacetic acid. Phenelzine also elevates brain GABA levels, and as yet unidentified… CONTINUE READING
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