Metabolism of Methylisoeugenol in Liver Microsomes of Human, Rat, and Bovine Origin

@article{Cartus2011MetabolismOM,
  title={Metabolism of Methylisoeugenol in Liver Microsomes of Human, Rat, and Bovine Origin},
  author={Alexander T. Cartus and K H Merz and Dieter Schrenk},
  journal={Drug Metabolism and Disposition},
  year={2011},
  volume={39},
  pages={1727 - 1733}
}
Methylisoeugenol (1,2-dimethoxy-4-propenylbenzene, 1) is a minor constituent of essential oils, naturally occurring as a mixture of cis/trans isomers. 1 is a U.S. Food and Drug Administration-approved food additive and has been given “Generally Recognized as Safe” status. Previously, metabolism of 1 has been studied in the rat, revealing mainly nontoxic cinnamoyl derivatives as major metabolites. However, data concerning the possible formation of reactive intermediary metabolites are not… 

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