Metabolism of MK-0524, a prostaglandin D2 receptor 1 antagonist, in microsomes and hepatocytes from preclinical species and humans.

@article{Dean2007MetabolismOM,
  title={Metabolism of MK-0524, a prostaglandin D2 receptor 1 antagonist, in microsomes and hepatocytes from preclinical species and humans.},
  author={Brian J. Dean and Steve Chang and Maria Victoria Silva Elipe and Yuan-qing Xia and Matt Braun and Eric Soli and Yuming Zhao and Ronald B. Franklin and Bindhu V. Karanam},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2007},
  volume={35 2},
  pages={283-92}
}
(3R)-4-(4-Chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl acetic acid (MK-0524) is a potent orally active human prostaglandin D(2) receptor 1 antagonist that is currently under development for the prevention of niacin-induced flushing. The major in vitro and in vivo metabolite of MK-0524 is the acyl glucuronic acid conjugate of the parent compound, M2. To compare metabolism of MK-0524 across preclinical species and humans, studies were undertaken to determine… CONTINUE READING
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