Metabolism of GTI-2040, a phosphorothioate oligonucleotide antisense, using ion-pair reversed phase high performance liquid chromatography (HPLC) coupled with electrospray ion-trap mass spectrometry

Abstract

GTI-2040 is a 20-mer phosphorothioate oligonucleotide, which is complementary to the messenger ribonucleic acid (mRNA) of the R2 subunit of ribonucleotide reductase. This study characterized both the in vivo and in vitro metabolism of GTI-2040. A highly specific ion-pair reversed-phase electrospray ionization (IP-RP-ESI) liquid chromatographymass… (More)
DOI: 10.1208/aapsj080484

Topics

12 Figures and Tables

Cite this paper

@article{Wei2006MetabolismOG, title={Metabolism of GTI-2040, a phosphorothioate oligonucleotide antisense, using ion-pair reversed phase high performance liquid chromatography (HPLC) coupled with electrospray ion-trap mass spectrometry}, author={Xiaohui Wei and Guowei Dai and Zhongfa Liu and Hao Cheng and Zhiliang Xie and Guido Marcucci and Kenneth K. Chan}, journal={The AAPS Journal}, year={2006}, volume={8}, pages={E743-E755} }