Metabolism of EICAR (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide), a potent inhibitor of inosinate dehydrogenase.

  title={Metabolism of EICAR (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide), a potent inhibitor of inosinate dehydrogenase.},
  author={Jan Balzarini and L. Stet and Akira Minamishinkawa-K Matsuda and Leonard I Wiebe and Elizabeth B. Knauss and Erik De Clercq},
  journal={Advances in experimental medicine and biology},
The cytostatic agent 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR) causes a rapid and marked inhibition of inosinate (IMP) dehydrogenase activity in intact tumor cells. [3H]EICAR is metabolised in L1210 cells to its 5'-mono-, 5'-di- and 5'-triphosphate in a concentration-dependent manner. The metabolites accumulate proportionally with the initial extracellular EICAR concentrations (ranging from 0.25 to 200 microM). The nicotinamide adenine dinucleotide (NAD) analogue of EICAR… Expand
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Preface to Nucleosides, Nucleotides & Nucleic Acids issue honoring the 70th birthday of Professor Akira Matsuda
  • N. Minakawa
  • Medicine, Chemistry
  • Nucleosides, nucleotides & nucleic acids
  • 2020
This special issue of Nucleosides, Nucleotides & Nucleic Acids is introduced in celebration of the 70th birthday of Professor Akira Matusda, Emeritus Professor of Hokkaido University, whose research background is consistently medicinal chemistry based on nucleoside derivatives. Expand