Metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus), by human liver microsomes.

@article{Nikolic2004MetabolismO8,
  title={Metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus), by human liver microsomes.},
  author={D. Nikolic and Y. Li and L. Chadwick and S. Grubjesic and P. Schwab and P. Metz and R. V. van Breemen},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2004},
  volume={32 2},
  pages={
          272-9
        }
}
The female flowers of hops are used throughout the world as a flavoring agent for beer. Recently, there has been increasing interest in the potential estrogenic properties of hop extracts. Among the possible estrogenic compounds in hops, 8-prenylnaringenin is perhaps most significant due to its high in vitro potency exceeding that of other known phytoestrogens. Since data regarding the pharmacokinetic properties of this compound are lacking, we investigated the in vitro metabolism of 8… Expand
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