Metabolism of 5 alpha reduced androgens by various tissues of the male rat.

@article{Pasupuleti1990MetabolismO5,
  title={Metabolism of 5 alpha reduced androgens by various tissues of the male rat.},
  author={Vijaya Pasupuleti and Richard F. Horton},
  journal={Journal of andrology},
  year={1990},
  volume={11 2},
  pages={
          161-7
        }
}
Since an animal model for the study of peripheral androgen metabolism is needed, we studied the metabolism of 5 alpha-reduced androgens in various tissues of the rat. Labeled DHT and 3 alpha androstanediol (3 alpha diol) were added to tissue minces of male rat scrotal skin, muscle, prostate, or liver. Conversion ratios of the interconverting pair DHT in equilibrium with 3 alpha diol or the formation of the respective glucuronides (G) were determined over a 3 h period. Major differences in the… CONTINUE READING

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