Metabolism of 36Cl-ornidazole after oral application to the male rat in relation to its antifertility activity.

@article{Jones1997MetabolismO3,
  title={Metabolism of 36Cl-ornidazole after oral application to the male rat in relation to its antifertility activity.},
  author={A. Jones and T. Cooper},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1997},
  volume={27 7},
  pages={
          711-21
        }
}
  • A. Jones, T. Cooper
  • Published 1997
  • Biology, Medicine, Chemistry
  • Xenobiotica; the fate of foreign compounds in biological systems
  • 1. The antimycotic ornidazole (a male antifertility agent in rats) was synthesized incorporating 36Cl in the chloropropyl sidechain and its metabolism was investigated in the male rat after oral ingestion. 2. Blood levels of radioactivity were low over the first 24 h and there was no tissue accumulation of radioactivity over 48 h. 3. Most of the excreted radioactivity (20% of the ingested dose) appeared in the urine within the first 24 h. 4. Three major compounds were detected in 0-24-h urine… CONTINUE READING
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