Metabolism of 3-indolylacetic acid during percutaneous absorption in human skin.

@article{Ademola1993MetabolismO3,
  title={Metabolism of 3-indolylacetic acid during percutaneous absorption in human skin.},
  author={John I. Ademola and Ronald C. Wester and Howard Ira Maibach},
  journal={Journal of pharmaceutical sciences},
  year={1993},
  volume={82 2},
  pages={150-4}
}
This study assessed the in vitro percutaneous absorption and metabolism of 3-indolylacetic acid after topical dosing to human skin from four sources. The metabolism of the compound during percutaneous absorption was assessed. The absorbed and metabolized chemicals were analyzed by radioactive scintillation counting and thin-layer chromatography: 1.2% +/- 0.04%, 1.4% +/- 0.07%, 3.0% +/- 1.0%, and 0.1% +/- 0.02% of the applied doses permeated through human skin samples from sources A to D… CONTINUE READING