Metabolism of 3-deoxyglucosone, an intermediate compound in the Maillard reaction, administered orally or intravenously to rats.

@article{Kato1990MetabolismO3,
  title={Metabolism of 3-deoxyglucosone, an intermediate compound in the Maillard reaction, administered orally or intravenously to rats.},
  author={H. Ogata H. Kato and Nguyen Van Chuyen and Takehiro Shinoda and Fujio Sekiya and Fumitaka Hayase},
  journal={Biochimica et biophysica acta},
  year={1990},
  volume={1035 1},
  pages={71-6}
}
The Amadori rearrangement compound, the product in the early step of the Maillard reaction of proteins with glucose, is known to be degraded into 3-deoxyglucosone (3DG), a 2-oxoaldehyde. In order to elucidate the metabolic pathway of 3DG, [14C]3DG was synthesized from [14C]-glucose and administered to rats orally and intravenously. 2 h after oral administration of [14C]3DG, the percentages of radioactivity (RaI%) in stomach, small intestine and urine were 3.9, 60 and 6.4%, respectively, while… CONTINUE READING

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