Metabolism of 25-hydroxyvitamin D in copper-laden rat: a model of Wilson's disease.

@article{Carpenter1988MetabolismO2,
  title={Metabolism of 25-hydroxyvitamin D in copper-laden rat: a model of Wilson's disease.},
  author={Thomas O. Carpenter and Micheal L. Pendrak and Constantine S Anast},
  journal={The American journal of physiology},
  year={1988},
  volume={254 2 Pt 1},
  pages={E150-4}
}
Wilson's disease results in excess tissue accumulation of copper and is often complicated by skeletal and mineral abnormalities. We investigated vitamin D metabolism in rats fed a copper-laden diet rendering hepatic copper content comparable with that found in Wilson's disease. Injection of 25-hydroxyvitamin D3 [25(OH)D3] resulted in reduced 1,25-dihydroxyvitamin D [1,25(OH)2D] levels in copper-intoxicated rats. In vitro 25(OH)D-1 alpha-hydroxylase activity was impaired in renal mitochondria… CONTINUE READING