Metabolism of 2-hydroxy-3-deoxyestradiol by rat liver microsomes.

@article{Numazawa1977MetabolismO2,
  title={Metabolism of 2-hydroxy-3-deoxyestradiol by rat liver microsomes.},
  author={M. Numazawa and N. Soeda and S. Moro and T. Nambara},
  journal={Biochemical pharmacology},
  year={1977},
  volume={26 8},
  pages={
          769-73
        }
}
Abstract The biotransformation of [6,7-3H]2-hydroxy-3-deoxyestradiol, which is a positional isomer of the naturally occurring estrogen, has been investigated with rat liver microsomes. 2-Hydroxyestradiol separated from the lipophilic fraction of the incubation mixture was unequivocally characterized by means of thin-layer chromatography, gas chromatography-mass spectrometry, and the reverse isotope dilution method. The formation of glutathione 1- and 4-thioethers of 2-hydroxyestradiol as… Expand
9 Citations
A simple radiometric assay for estradiol 2-hydroxylase activity.
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