Metabolism of 2-hexadecynoate and inhibition of fatty acid elongation.

  title={Metabolism of 2-hexadecynoate and inhibition of fatty acid elongation.},
  author={Randall Wood and Tae-Hee Lee},
  journal={The Journal of biological chemistry},
  volume={256 23},
Dietary methyl-2-hexadecynoate appeared to inhibit fatty acid elongation in intact animals (Wood, R., Lee, T., and Gershon, H. (1980) Lipids 15, 141-150). Data from the present in vitro studies indicate that the microsomal elongation system is inhibited preferentially to the mitochondrial system. A series of metabolic acyl-CoA thioester intermediates has been isolated, characterized, and identified from microsomal and mitochondrial incubations with the 2-hexadecynoic acid (16 identical to 1… CONTINUE READING


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