Metabolism of 2-[18F]fluoro-2-deoxyglucose in tumor-bearing rats: chromatographic and enzymatic studies.

@article{Suolinna1986MetabolismO2,
  title={Metabolism of 2-[18F]fluoro-2-deoxyglucose in tumor-bearing rats: chromatographic and enzymatic studies.},
  author={E M Suolinna and Merja Haaparanta and Robert Paul and Pirkko L. H{\"a}rk{\"o}nen and Olof Solin and Hannu T. Sipil{\"a}},
  journal={International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology},
  year={1986},
  volume={13 5},
  pages={577-81}
}
The activities of hexokinase and glucose-6-phosphatase, as well as the in vivo metabolic products of 2-[18F]fluoro-2-deoxyglucose ([18F]FDG) (45 min after an i.v. injection), were determined from several tissues of Rous sarcoma implanted rats. The HK/G-6-Pase ratio was found to be high in brain and tumor, and low in liver with intermediate values for kidney and muscle. In accordance with the measured enzyme activities about 90% of the 18F was found as [18F]FDG-6-P in brain, heart and tumor… CONTINUE READING