Metabolism of 2,4-dinitrotoluene and 2,6-dinitrotoluene, and their dinitrobenzyl alcohols and dinitrobenzaldehydes by Wistar and Sprague-Dawley rat liver microsomal and cytosol fractions.

@article{Mori1989MetabolismO2,
  title={Metabolism of 2,4-dinitrotoluene and 2,6-dinitrotoluene, and their dinitrobenzyl alcohols and dinitrobenzaldehydes by Wistar and Sprague-Dawley rat liver microsomal and cytosol fractions.},
  author={M A Mori and T Kawajiri and Michio Sayama and Tatsuro Miyahara and Hiroshi Kozuka},
  journal={Chemical \& pharmaceutical bulletin},
  year={1989},
  volume={37 7},
  pages={
          1904-8
        }
}
The metabolism of 2,4-dinitrotoluene (2,4-DNT), 2,4-dinitrobenzyl alcohol (2,4-DNB), 2,4-dinitrobenzaldehyde (2,4-DNBAl), 2,6-DNT, 2,6-DNB and 2,6-DNBAl in the microsomal and cytosol fractions prepared from unfortified male Wistar and male Sprague-Dawley (S.D.) rat livers was investigated. Data obtained by high-performance liquid chromatography (HPLC) indicated that the products of dinitrotoluenes (2,4-DNT and 2,6-DNT), dinitrobenzyl alcohols (2,4-DNB and 2,6-DNB), and dinitrobenzaldehydes (2,4… 
Biliary excretion and microfloral transformation of major conjugated metabolites of 2,4-dinitrotoluene and 2,6-dinitrotoluene in the male Wistar rat.
  • M. Mori, M. Sayama, T. Honda
  • Chemistry, Biology
    Xenobiotica; the fate of foreign compounds in biological systems
  • 1997
1. Major biliary conjugates of the male Wistar rat dosed orally with 2,4-dinitrotoluene (2,4-DNT) or 2,6-dinitrotoluene (2,6-DNT) were examined by hplc using potassium 2,4-dinitrobenzyl glucuronide
Metabolism and Pharmacokinetics of 3n-Butylphthalide ( NBP ) in Humans : The Role of Cytochrome P 450 s and Alcohol Dehydrogenase in Biotransformation s
TLDR
Overall, the study demonstrated that NBP was well absorbed and extensively metabolized by multiple enzymes to various metabolites prior to treatment of cerebral ischemia.
Metabolism and Pharmacokinetics of 3-n-Butylphthalide (NBP) in Humans: The Role of Cytochrome P450s and Alcohol Dehydrogenase in Biotransformation
TLDR
It is demonstrated that NBP was well absorbed and extensively metabolized by multiple enzymes to various metabolites prior to urinary excretion, and can undergo β-oxidation to yield phthalide-3-acetic acid in rat liver homogenate.
Identification of human cytochrome P450 enzymes involved in the major metabolic pathway of fluvoxamine
  • M. Miura, T. Ohkubo
  • Chemistry, Medicine
    Xenobiotica; the fate of foreign compounds in biological systems
  • 2007
TLDR
The data suggest that CYP2D6 is the only enzyme predominantly responsible for the first-step oxidation of fluvoxamine to fluv oxamino alcohol, and alcohol dehydrogenase is involved in the second- step oxidation offluvoxaminos alcohol to the corresponding carbolic acid.
The metabolism of olaquindox in rats, chickens and pigs.
...
1
2
...