Metabolism of 2,2',5,5'-tetrachlorobiphenyl: formation of mono- and bis-methyl sulphone metabolites with a selective affinity for the lung and kidney tissues in mice.

Abstract

1. Distribution in mice of 2,2',5,5'-tetrachloro[14C]biphenyl has been studied by autoradiography. Radioactivity was specifically localized in the bronchial epithelium, the lung parenchyma, the kidney cortex and the adipose tissue. 2. Bis(methylsulphonyl)-2,2',5,5'-tetrachlorobiphenyl, a hitherto unknown metabolite of 2,2',5,5'-tetrachlorobiphenyl, has been… (More)

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