Metabolism of 1,2,4-trichlorobenzene in rats: examination of thiol formation.

Abstract

1. More than 60% of oral doses of 14C-1,2,4-trichlorobenzene (ca. 21 mg/kg) administered to rats were excreted in bile as S-trichlorophenyl-mercapturic acid pathway metabolites. 2. The biliary metabolites were ultimately excreted in urine mainly as the isomeric mercapturic acids. 3. An acetylated glutathione conjugate was isolated as a major metabolite in bile (8% dose). The acetyl group was shown by mass spectrometry to be on the glutamyl moiety. 4. A glutamylcysteine conjugate of trichlorobenzene was also isolated from bile as a major metabolite (8% dose). 5. Trichlorothiophenols were deduced not to be intermediates or end-products of enzymic metabolism of trichlorobenzene in rats because 14C-2,4,5-trichlorothiophenol dosed i.p. to rats was excreted as the S-glucuronide (17% dose) and as S-(methylsulphonyl-dichlorophenyl)-mercapturic acid (36% dose).

Cite this paper

@article{Bakke1992MetabolismO1, title={Metabolism of 1,2,4-trichlorobenzene in rats: examination of thiol formation.}, author={Jerome E. Bakke and Janice K. Huwe and Darcy J Mulford and {\AA}ke Lennart Bergman}, journal={Xenobiotica; the fate of foreign compounds in biological systems}, year={1992}, volume={22 2}, pages={199-210} }