Metabolism of 1,8-cineole by human cytochrome P450 enzymes: identification of a new hydroxylated metabolite.

@article{Duisken2005MetabolismO1,
  title={Metabolism of 1,8-cineole by human cytochrome P450 enzymes: identification of a new hydroxylated metabolite.},
  author={Mike Duisken and Frank Sandner and Brunhilde Bl{\"o}meke and Juliane Hollender},
  journal={Biochimica et biophysica acta},
  year={2005},
  volume={1722 3},
  pages={
          304-11
        }
}
Human metabolism of the monoterpene cyclic ether 1,8-cineole was investigated in vitro and in vivo. In vitro, the biotransformation of 1,8-cineole was investigated by human liver microsomes and by recombinant cytochrome P450 enzymes coexpressed with human CYP-reductase in Escherichia coli cells. Besides the already described metabolite 2alpha-hydroxy-1,8-cineole we found another metabolite produced at high rates. The structure was identified by a comparison of its mass spectrum and retention… CONTINUE READING
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