Metabolism of 1,3-butadiene to toxicologically relevant metabolites in single-exposed mice and rats.

@article{Filser2007MetabolismO1,
  title={Metabolism of 1,3-butadiene to toxicologically relevant metabolites in single-exposed mice and rats.},
  author={Johannes Georg Filser and Christoph Hutzler and Veronika Meischner and Vimal Veereshwarayya and Gy{\"o}rgy Andr{\'a}s Csan{\'a}dy},
  journal={Chemico-biological interactions},
  year={2007},
  volume={166 1-3},
  pages={
          93-103
        }
}
1,3-Butadiene (BD) was carcinogenic in rodents. This effect is related to reactive metabolites such as 1,2-epoxy-3-butene (EB) and especially 1,2:3,4-diepoxybutane (DEB). A third mutagenic epoxide, 3,4-epoxy-1,2-butanediol (EBD), can be formed from DEB and from 3-butene-1,2-diol (B-diol), the hydrolysis product of EB. In BD exposed rodents, only blood concentrations of EB and DEB have been published. Direct determinations of EBD and B-diol in blood are missing. In order to investigate the BD… CONTINUE READING

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