• Corpus ID: 46406612

Metabolism of (R)-(+)-pulegone and (R)-(+)-menthofuran by human liver cytochrome P-450s: evidence for formation of a furan epoxide.

@article{KhojastehBakht1999MetabolismO,
  title={Metabolism of (R)-(+)-pulegone and (R)-(+)-menthofuran by human liver cytochrome P-450s: evidence for formation of a furan epoxide.},
  author={Siamak Cyrus Khojasteh-Bakht and W Chen and Luke L. Koenigs and Raimund M. Peter and Sidney D. Nelson},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1999},
  volume={27 5},
  pages={
          574-80
        }
}
(R)-(+)-Pulegone, a monoterpene constituent of pennyroyal oil, is a hepatotoxin that has been used in folklore medicine as an abortifacient despite its potential lethal effects. Pulegone is metabolized by human liver cytochrome P-450s to menthofuran, a proximate hepatotoxic metabolite of pulegone. Expressed human liver cytochrome (CYP) P-450s (1A2, 2A6, 2C9, 2C19, 2D6, 2E1, and 3A4) were tested for their ability to catalyze the oxidations of pulegone and menthofuran. Expressed CYP2E1, CYP1A2… 

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