Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes.

@article{Miyazawa2002MetabolismO,
  title={Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes.},
  author={Mitsuo Miyazawa and Masaki Shindo and Tsutomu Shimada},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2002},
  volume={30 5},
  pages={
          602-7
        }
}
Limonene, a monocyclic monoterpene, is present in orange peel and other plants and has been shown to have chemopreventive activities. (+)- and (-)-Limonene enantiomers were incubated with human liver microsomes and the oxidative metabolites thus formed were analyzed using gas chromatography-mass spectrometry. Two kinds of metabolites, (+)- and (-)-trans-carveol (a product by 6-hydroxylation) and (+)- and (-)-perillyl alcohol (a product by 7-hydroxylation), were identified, and the latter… Expand
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Investigating whether (+)- and (-)-limonene enantiomers are differentially metabolized by P450 enzymes in liver microsomes of mice, rats, guinea pigs, rabbits, dogs, monkeys, and humans suggests that there are species-related differences in the metabolism of limonenes by P 450 enzymes. Expand
ROLES OF HUMAN CYP 2 A 6 AND 2 B 6 AND RAT CYP 2 C 11 AND 2 B 1 IN THE 10-HYDROXYLATION OF ( )-VERBENONE BY LIVER MICROSOMES
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CYP2A6 in human liver microsomes was a major enzyme involved in the oxidation of (−)-terpinen-4-ol by human livermicrosomes, based on the following lines of evidence. Expand
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TLDR
The present results show that there are sex-related differences in the oxidative metabolism of limonene enantiomers by liver microsomes, which may provide useful information on the basis ofLimonene-induced toxicities in different animal species. Expand
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TLDR
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The view that CYP2D6*3,*4, *4D, and *4L are major genotypes producing poor metabolizer phenotypes in CYP 2D6 in Caucasians is supported, whereas CYP1A2 is a major factor in decreased CYP3D6 protein expression and catalytic activities in Japanese. Expand
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TLDR
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