Metabolism of [3H]oestradiol in vivo by normal breast and tumour tissue in postmenopausal women.

@article{Bonney1986MetabolismO,
  title={Metabolism of [3H]oestradiol in vivo by normal breast and tumour tissue in postmenopausal women.},
  author={Roseanne Bonney and Michael J. Reed and P A Beranek and Margaret W Ghilchik and Vivian H T James},
  journal={Journal of steroid biochemistry},
  year={1986},
  volume={24 1},
  pages={361-4}
}
Tumour and normal breast tissue was obtained from postmenopausal breast cancer patients following [3H]oestradiol infusion (50 mu Ci over a 12 h period). The fraction of radioactivity present as oestradiol or oestrone was measured and the results expressed both as the ratio of oestradiol-oestrone and as the percentage oestrogen present as oestrone, and the findings compared with in vitro measurements of 17 beta-hydroxysteroid dehydrogenase activity. Concentrations of 5-androstene-3 beta, 17 beta… CONTINUE READING