Metabolism of [14C]arachidonic acid by polymorphonuclear leukocytes in patients with psoriasis.

  title={Metabolism of [14C]arachidonic acid by polymorphonuclear leukocytes in patients with psoriasis.},
  author={M St{\"u}ning and Ulrich Schultz-Ehrenburg and Peter Josef Altmeyer and Monika Raulf and W. K{\"o}nig},
  journal={The British journal of dermatology},
  volume={116 2},
The formation of LTB4 and its omega-oxidation products 20-hydroxy- and 20-carboxy-LTB4 from exogenous [14C]arachidonic acid (AA) by neutrophils from 12 psoriatic patients and 10 healthy controls was investigated. Only a slight difference was detected in the mean amount of [14C]LTB4 produced. In contrast, the amounts of [14C]omega-oxidation products obtained from psoriatic PMN were 2.4-fold higher than the amounts from PMN of healthy controls. We conclude that in vitro, psoriatic PMN synthesize… CONTINUE READING

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