Metabolism of [1-(13)C)glucose and [2-(13)C]acetate in the hypoxic rat brain..

  title={Metabolism of [1-(13)C)glucose and [2-(13)C]acetate in the hypoxic rat brain..},
  author={J F Chateil and Marc Biran and Eric Thiaudi{\'e}re and Paul Canioni and Michel Merle},
  journal={Neurochemistry international},
  volume={38 5},
The effects of hypoxia on the metabolism of the central nervous system were investigated in rats submitted to a low oxygen atmosphere (8% O(2); 92% N(2)). [1-(13)C]glucose and [2-(13)C]acetate were used as substrates, this latter being preferentially metabolized by glial cells. After 1-h substrate infusion, the incorporation of 13C in brain metabolites was determined by NMR spectroscopy. Under hypoxia, an important hyperglycemia was noted. As a consequence, when using labeled glucose, the… CONTINUE READING


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