Metabolism is required for the expression of ecstasy-induced cardiotoxicity in vitro.

@article{Carvalho2004MetabolismIR,
  title={Metabolism is required for the expression of ecstasy-induced cardiotoxicity in vitro.},
  author={M{\'a}rcia Carvalho and Fernando Remi{\~a}o and Nuno Milhazes and Fernanda Borges and Eduarda Fernandes and Maria do C{\'e}u Monteiro and Maria Jos{\'e} Gonçalves and V{\'i}tor Seabra and Francisco Ml Amado and F{\'e}lix Carvalho and Maria de Lourdes Bastos},
  journal={Chemical research in toxicology},
  year={2004},
  volume={17 5},
  pages={623-32}
}
Cardiovascular complications associated with 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) abuse have increasingly been reported. The indirect effect of MDMA mediated by a sustained high level of circulating biogenic amines may contribute to the cardiotoxic effects, but other factors, like the direct toxic effects of MDMA and its metabolites in cardiac cells, remain to be investigated. Thus, the objective of the present in vitro study was to evaluate the potential cardiotoxic effects of… CONTINUE READING
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