Metabolism in T cell activation and differentiation.

@article{Pearce2010MetabolismIT,
  title={Metabolism in T cell activation and differentiation.},
  author={Erika L Pearce},
  journal={Current opinion in immunology},
  year={2010},
  volume={22 3},
  pages={314-20}
}
When naïve or memory T cells encounter foreign antigen along with proper co-stimulation they undergo rapid and extensive clonal expansion. In mammals, this type of proliferation is fairly unique to cells of the adaptive immune system and requires a considerable expenditure of energy and cellular resources. While research has often focused on the roles of cytokines, antigenic signals, and co-stimulation in guiding T cell responses, data indicate that, at a fundamental level, it is cellular… CONTINUE READING
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