Metabolism and trafficking of N-type voltage-operated calcium channels in neurosecretory cells.

@article{Sher1998MetabolismAT,
  title={Metabolism and trafficking of N-type voltage-operated calcium channels in neurosecretory cells.},
  author={Emanuele Sher and Patrizia Di Rosa and Maura Francolini and Agnese Codignola and E Morlacchi and Elena Taverna and Federica Giovannini and Angelica Brioschi and Francesco Clementi and Maureen W. McEnery and Maria Passafaro},
  journal={Journal of bioenergetics and biomembranes},
  year={1998},
  volume={30 4},
  pages={399-407}
}
The N-type voltage-operated calcium channel has been characterized over the years as a high-threshold channel, with variable inactivation kinetics, and a unique ability to bind with high affinity and specificity omega-conotoxin GVIA and related toxins. This channel is particularly expressed in some neurons and endocrine cells, where it participates in several calcium-dependent processes, including secretion. Omega-conotoxin GVIA was instrumental not only for the biophysical and pharmacological… CONTINUE READING
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