Metabolism and the Microbiome Defining the Role of Gut Bacteria in the Metabolism of Deleobuvir : In Vitro and In Vivo Studies

@inproceedings{McCabe2015MetabolismAT,
  title={Metabolism and the Microbiome Defining the Role of Gut Bacteria in the Metabolism of Deleobuvir : In Vitro and In Vivo Studies},
  author={Michelle M. McCabe and Rucha S. Sane and Monica Keith-Luzzi and Jun Xu and Illeaniz King and Andrea Whitcher-Johnstone and Nicholas Johnstone and Donald J. Tweedie and Yongmei Li},
  year={2015}
}
Deleobuvir is a potent inhibitor of the hepatitis C virus nonstructural protein 5B polymerase. In humans, deleobuvir underwent extensive reduction to form CD 6168. This metabolite was not formed in vitro in aerobic incubations with human liver microsomes or cytosol. Anaerobic incubations of deleobuvir with rat and human fecal homogenates produced CD 6168. Using these in vitro formation rates, a retrospective analysis was conducted to assess whether the fecal formation of CD 6168 could account… CONTINUE READING