Metabolism and pulmonary toxicity of intratracheally instilled cupric sulfate in rats.

@article{Hirano1990MetabolismAP,
  title={Metabolism and pulmonary toxicity of intratracheally instilled cupric sulfate in rats.},
  author={Seishiro Hirano and Soichi Sakai and Hisae Ebihara and Naomi Kodama and Kazuo T. Suzuki},
  journal={Toxicology},
  year={1990},
  volume={64 3},
  pages={223-33}
}
Though copper (Cu)-handling workers are known to be at risk to develop metal fume fever and acute respiratory failure, very little is known about the metabolic fate and pulmonary toxicity of Cu compounds deposited in the lung. We have investigated time-course and dose-related changes in Cu contents, the production of metallothionein (MT) and inflammatory responses in the rat lung following intratracheal instillation of cupric sulfate (CuSO4). Intratracheally instilled Cu was cleared rapidly… CONTINUE READING

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