Metabolism and pharmacokinetics of selected halon replacement candidates.

@article{Dodd1993MetabolismAP,
  title={Metabolism and pharmacokinetics of selected halon replacement candidates.},
  author={Darol E. Dodd and Wayne T. Brashear and Allen Vinegar},
  journal={Toxicology letters},
  year={1993},
  volume={68 1-2},
  pages={
          37-47
        }
}

Physiologically based pharmacokinetic analysis of the concentration-dependent metabolism of halothane.

TLDR
A physiologically based pharmacokinetic model describing the concentration-dependent reduction in uptake and metabolism of halothane in male and female rats was developed and good simulation of urinary excretion data was interpreted to indicate that, when only 20% of the enzyme is inactivated, the rate of enzyme resynthesis was adequate to replenish enzyme activity within 24 h.

Hepatotoxicity in Guinea Pigs Following Acute Inhalation Exposure to 1,1-Dichloro-2,2,2-Trifluoroethane

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Similarities in the response between halothane and HCFC-123 in this guinea pig model suggests that humans susceptible to halothanes-induced hepatitis may be susceptible to HCFC -123 by a common mechanism of toxicity.

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TLDR
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TLDR
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TLDR
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