Metabolism and pharmacokinetics of prostaglandin E1 administered by intravenous infusion in human subjects

@article{Cawello2004MetabolismAP,
  title={Metabolism and pharmacokinetics of prostaglandin E1 administered by intravenous infusion in human subjects},
  author={Willi Cawello and Horst Schweer and Robert M{\"u}ller and Rainer Bonn and Hannsj{\"o}rg W. Seyberth},
  journal={European Journal of Clinical Pharmacology},
  year={2004},
  volume={46},
  pages={275-277}
}
In a single-blind, randomized, two-way crossover study with 12 healthy male volunteers, 60 μg of prostaglandin E1 (PGE1) or placebo was administered by intravenous infusion during a 120-min period. PGE1, 13,14-dihydro-PGE1 (PGE0) and 15-keto-PGE0 plasma concentrations were measured by a highly specific and sensitive GC-MS/MS method.Endogenous PGE1 plasma concentrations ranged between 1.2 and 1.8 pg·ml−1. Endogenous PGE0 and 15-keto-PGE0 plasma concentrations varied from 0.8 to 1.3 pg·ml−1 and… 
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References

SHOWING 1-10 OF 17 REFERENCES
On the metabolism of prostaglandin E1 administered intravenously to human volunteers.
TLDR
It was found that levels of 15-keto-13, 14-dihydro-PGE1, but not those of PGE1 itself, increased in a dose-dependent manner, and increased formation of 13,14-dismemberment-of-prostaglandin (PG) E1 with increasing doses of P GE1 can be expected to occur.
Metabolic disposition of prostaglandin E1 in man.
A radioimmunoassay for the unstable pulmonary metabolites of prostaglandin E1 and E2: an indirect index of their in vivo disposition and pharmacokinetics.
TLDR
A radioimmunoassay with a sensitivity of 12-pg was developed for this analytically suitable bicyclic derivative of prostaglandin E2 and the accuracy, precision and sensitivity of the method permitted its application to certain intractable problems.
Formation of biologically active 13,14-dihydro-prostaglandin E1 during intravenous infusion of prostaglandin E1 in newborns with ductus arteriosus-dependent congenital heart disease.
TLDR
Plasma concentrations of prostaglandin (PG) E1 and 13,14-dihydro-PGE1 were measured by gas chromatography-mass spectrometry in eight newborns with ductus arteriosus-dependent congenital heart disease during continuous intravenous infusion of PGE1.
Determination of prostaglandin E1 and its main plasma metabolites 15-keto-prostaglandin E0 and prostaglandin E0 by gas chromatography/negative ion chemical ionization triple-stage quadrupole mass spectrometry.
Prostaglandin E1 (PGE1), 15-keto-PGE0 and PGE0 in plasma were determined in an isotope dilution assay by gas chromatography/triple-stage quadrupole mass spectrometry. After addition of deuterated
On the Metabolism of Prostaglandins E1 and E2 in Man
Prostaglandin E1 and arterial occlusive disease: pharmacological considerations
TLDR
A large number of uncontrolled and small number of controlled clinical studies has been published claiming significant beneficial effects of PGEI therapy in patients with arterial occlusive disease, although some studies have suggested strong placebo effects.
Compartmental Model Analysis in Pharmacokinetics
TLDR
Compartmental model analysis appears to be a tool that is still used and remains useful in the fields of pharmacokinetics and clinical pharmacology, and the applications of compartmental models inclinical pharmacology are discussed.
Effect of iron deficiency anaemia and its treatment on sulphadimidine absorption
TLDR
Sulphadimidine absorption by the anaemic patients was significantly greater than in normals, and it was not significantly different before and after iron therapy or correction of anaemia.
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