Metabolism and pharmacokinetics of prostaglandin E1 administered by intravenous infusion in human subjects

@article{Cawello2004MetabolismAP,
  title={Metabolism and pharmacokinetics of prostaglandin E1 administered by intravenous infusion in human subjects},
  author={W. Cawello and H. Schweer and R. M{\"u}ller and R. Bonn and H. Seyberth},
  journal={European Journal of Clinical Pharmacology},
  year={2004},
  volume={46},
  pages={275-277}
}
In a single-blind, randomized, two-way crossover study with 12 healthy male volunteers, 60 μg of prostaglandin E1 (PGE1) or placebo was administered by intravenous infusion during a 120-min period. PGE1, 13,14-dihydro-PGE1 (PGE0) and 15-keto-PGE0 plasma concentrations were measured by a highly specific and sensitive GC-MS/MS method.Endogenous PGE1 plasma concentrations ranged between 1.2 and 1.8 pg·ml−1. Endogenous PGE0 and 15-keto-PGE0 plasma concentrations varied from 0.8 to 1.3 pg·ml−1 and… Expand
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