Metabolism and pharmacokinetics of N1,N11-diethylnorspermine.

  title={Metabolism and pharmacokinetics of N1,N11-diethylnorspermine.},
  author={Raymond J. Bergeron and William R. Weimar and Gabriel R Luchetta and Richard R. Streiff and Jan Wiegand and J E Perrin and Kurt Schreier and Cynthia Porter and Guocan Yao and H G Dimova},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={23 10},
The pharmacokinetics and metabolism of N1,N11-diethylnorspermine (DENSPM) is described. When administered to dogs as an intravenous bolus, DENSPM was shown to have a plasma half-life of 72.8 +/- 11.8 min, with an early distribution phase half-life of approximately 4 min and an apparent volume of distribution of 0.216 +/- 0.032 liter/kg. The renal clearance… CONTINUE READING