Metabolism and kinetics of amlodipine in man.

  title={Metabolism and kinetics of amlodipine in man.},
  author={Alan P Beresford and D McGibney and Michael J. Humphrey and Paul Macrae and D. A. Stopher},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  volume={18 2},
1. The disposition of amlodipine, R,S,2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl- 5- methoxycarbonyl-6-methyl-1,4-dihydropyridine has been studied in two human volunteers using single oral and intravenous doses of 14C-amlodipine. The drug was well absorbed by the oral route while the mean oral bioavailability for unchanged drug was 62.5%. 2. Renal elimination was the major route of excretion with about 60% of the dosed radioactivity recovered in urine. Mean total recovered… CONTINUE READING


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