Metabolism and functions of glutathione in brain

  title={Metabolism and functions of glutathione in brain},
  author={R. Dringen},
  journal={Progress in Neurobiology},
  • R. Dringen
  • Published 2000
  • Biology, Medicine
  • Progress in Neurobiology
  • The tripeptide glutathione is the thiol compound present in the highest concentration in cells of all organs. Glutathione has many physiological functions including its involvement in the defense against reactive oxygen species. The cells of the human brain consume about 20% of the oxygen utilized by the body but constitute only 2% of the body weight. Consequently, reactive oxygen species which are continuously generated during oxidative metabolism will be generated in high rates within the… CONTINUE READING
    1,455 Citations
    Glutathione Pathways in the Brain
    • 522
    Glutathione-Dependent Detoxification Processes in Astrocytes
    • 83
    Peroxide detoxification by brain cells
    • 347
    Regulation of neuronal glutathione synthesis.
    • 301
    • PDF
    Analysis of glutathione: implication in redox and detoxification.
    • 941
    [The action of oxidative stress induced by ethanol on the central nervous system (CNS)].
    • 32
    • Highly Influenced
    • PDF
    Influence of glutathione levels and activity of glutathione-related enzymes in the brains of tumor-bearing mice.
    • 25
    • Highly Influenced
    • PDF


    Modulation of the glutathione redox state in adult astrocytes.
    • 11
    Immunolocalization of glutathione reductase in the murine brain
    • 23
    Multiple roles of glutathione in the central nervous system.
    • 283
    Synthesis of the Antioxidant Glutathione in Neurons: Supply by Astrocytes of CysGly as Precursor for Neuronal Glutathione
    • 516
    • PDF
    Antioxidant defense of the brain: a role for astrocytes.
    • J. X. Wilson
    • Medicine
    • Canadian journal of physiology and pharmacology
    • 1997
    • 401
    • Highly Influential
    Neurotrophin regulation of energy homeostasis in the central nervous system.
    • 45
    Glutathione deficiency leads to mitochondrial damage in brain.
    • 413
    • PDF
    Glutathione: New candidate neuropeptide in the central nervous system
    • 63
    • Highly Influential