Metabolism and functions of glutathione in brain

@article{Dringen2000MetabolismAF,
  title={Metabolism and functions of glutathione in brain},
  author={R. Dringen},
  journal={Progress in Neurobiology},
  year={2000},
  volume={62},
  pages={649-671}
}
  • R. Dringen
  • Published 2000
  • Biology, Medicine
  • Progress in Neurobiology
    • The tripeptide glutathione is the thiol compound present in the highest concentration in cells of all organs. Glutathione has many physiological functions including its involvement in the defense against reactive oxygen species. The cells of the human brain consume about 20% of the oxygen utilized by the body but constitute only 2% of the body weight. Consequently, reactive oxygen species which are continuously generated during oxidative metabolism will be generated in high rates within the… CONTINUE READING
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    References

    SHOWING 1-10 OF 379 REFERENCES
    Modulation of the glutathione redox state in adult astrocytes.
    • 11
    Immunolocalization of glutathione reductase in the murine brain
    • 23
    Multiple roles of glutathione in the central nervous system.
    • 283
    Microglial Cells in Culture Express a Prominent Glutathione System for the Defense against Reactive Oxygen Species
    • 81
    Distribution of glutathione and glutathione-related enzyme systems in mitochondria and cytosol of cultured cerebellar astrocytes and granule cells
    • 122
    Synthesis of the Antioxidant Glutathione in Neurons: Supply by Astrocytes of CysGly as Precursor for Neuronal Glutathione
    • 516
    • PDF
    Antioxidant defense of the brain: a role for astrocytes.
    • J. X. Wilson
    • Medicine
    • Canadian journal of physiology and pharmacology
    • 1997
    • 401
    • Highly Influential
    Neurotrophin regulation of energy homeostasis in the central nervous system.
    • 45
    Glutathione deficiency leads to mitochondrial damage in brain.
    • 413
    • PDF
    Glutathione: New candidate neuropeptide in the central nervous system
    • 63
    • Highly Influential