Metabolism and functions of glutathione in brain

@article{Dringen2000MetabolismAF,
  title={Metabolism and functions of glutathione in brain},
  author={Ralf Dringen},
  journal={Progress in Neurobiology},
  year={2000},
  volume={62},
  pages={649-671}
}
  • R. Dringen
  • Published 15 December 2000
  • Biology
  • Progress in Neurobiology

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References

SHOWING 1-10 OF 375 REFERENCES

Modulation of the glutathione redox state in adult astrocytes.

TLDR
Test the effects of several known modulators of thiol groups on the intracellular glutathione redox state, energy metabolism (ATP concentration) and cell viability (indicated by release of lactate dehydrogenase (LDH)).

Multiple roles of glutathione in the central nervous system.

TLDR
Patients with inborn errors of glutathione metabolism often exhibit progressive neurological problems, and increasing brainglutathione levels may have therapeutic benefits.

Immunolocalization of glutathione reductase in the murine brain

TLDR
The results show a specific localization of glutathione reductase in distinct brain regions, suggesting a variable potency of different brain areas in dealing with the damaging oxidative actions of free radicals.

Microglial Cells in Culture Express a Prominent Glutathione System for the Defense against Reactive Oxygen Species

TLDR
The results demonstrate that microglial cells have a prominent glutathione system, which is likely to reflect the necessity for self-protection against reactive oxygen species when produced by these or surrounding brain cells.

Synthesis of the Antioxidant Glutathione in Neurons: Supply by Astrocytes of CysGly as Precursor for Neuronal Glutathione

TLDR
The data suggest the following metabolic interaction in glutathione metabolism of brain cells: the ectoenzyme γ-glutamyl transpeptidase uses as substrate the glutATHione released by astrocytes to generate the dipeptide CysGly that is subsequently used by neurons as precursor for glutathion synthesis.

Antioxidant defense of the brain: a role for astrocytes.

  • J. Wilson
  • Biology
    Canadian journal of physiology and pharmacology
  • 1997
TLDR
Following reactive gliosis, the neuroprotective role of astrocytes may be accentuated because of increases in a number of activities: expression of antioxidant enzymes; transport and metabolism of glucose that yields reducing equivalents for antioxidant regeneration and lactate for neuronal metabolism; synthesis of glutathione; and recycling of vitamin C.

Glutathione deficiency leads to mitochondrial damage in brain.

TLDR
It is suggested that in glutathione deficiency, hydrogen peroxide accumulates and damages mitochondria and has an essential function in mitochondria under normal physiological conditions.

Neurotrophin regulation of energy homeostasis in the central nervous system.

TLDR
It is proposed that neurotrophin-mediated cell-sparing reflects effects on oxidant homeostasis in the face of increased levels of reactive oxygen species, decreased endogenous antioxidants, and impaired energy metabolism associated with physiological senescence, Alzheimer's, and Parkinson's diseases.
...