Metabolism and functions of glutathione in brain

@article{Dringen2000MetabolismAF,
  title={Metabolism and functions of glutathione in brain},
  author={Ralf Dringen},
  journal={Progress in Neurobiology},
  year={2000},
  volume={62},
  pages={649-671}
}
  • R. Dringen
  • Published 2000
  • Biology, Medicine
  • Progress in Neurobiology
The tripeptide glutathione is the thiol compound present in the highest concentration in cells of all organs. Glutathione has many physiological functions including its involvement in the defense against reactive oxygen species. The cells of the human brain consume about 20% of the oxygen utilized by the body but constitute only 2% of the body weight. Consequently, reactive oxygen species which are continuously generated during oxidative metabolism will be generated in high rates within the… Expand
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The regulatory mechanism of neuronal GSH production mediated by EAAC1 may be a new target in therapeutic strategies for these neurodegenerative diseases. Expand
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