Metabolism and excretion of zafirlukast in dogs, rats, and mice.

  title={Metabolism and excretion of zafirlukast in dogs, rats, and mice.},
  author={Rodney Savidge and K. H. Le Quan Bui and Bruce K. Birmingham and Jonathan L Morse and R C Spreen},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={26 11},
The in vivo metabolism and excretion of zafirlukast [Accolate; 4, 5-cyclopentoxycarbonylamino-3-[(2-methoxy-4,2- methylphenylsulfonylaminocarbonyl)phenylmethyl]-1-methylindole], a selective peptide leukotriene receptor agonist, were investigated in mice, rats, and dogs. Leukotrienes are a class of compounds that have been identified as being responsible for the contraction of human airway and lung vascular smooth muscle. A chemical agent that is effective in blocking the induced constricting… CONTINUE READING