Metabolism and excretion of tolcapone, a novel inhibitor of catechol-O-methyltransferase.

@article{Jorga1999MetabolismAE,
  title={Metabolism and excretion of tolcapone, a novel inhibitor of catechol-O-methyltransferase.},
  author={Karin M. Jorga and Barbel Fotteler and Philippe Heizmann and Robert E. Gasser},
  journal={British journal of clinical pharmacology},
  year={1999},
  volume={48 4},
  pages={
          513-20
        }
}
AIMS To investigate the rate of excretion and routes of metabolism of tolcapone, a novel inhibitor of catechol-O-methyltransferase (COMT). METHODS Six healthy male volunteers were given 200 mg [14C]-tolcapone (approximately 50 muCi) orally. To assess excretion balance and to identify metabolites, urine and faeces were collected before administration and until radioactivity fell below 75 d min-1 ml-1 (urine) and 100 d min-1 mg-1 (faeces). Blood samples were collected frequently before and… CONTINUE READING
BETA

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