Metabolism and excretion of a new antipsychotic drug, ziprasidone, in humans.

  title={Metabolism and excretion of a new antipsychotic drug, ziprasidone, in humans.},
  author={C. T. Jaya Prakash and Amr I. Kamel and J Gummerus and Kalman Wilner},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={25 7},
The pharmacokinetics, metabolism, and excretion of a new antipsychotic drug, ziprasidone, were studied in four normal male volunteers after oral administration of a single 20 mg dose of a mixture of 14C- and 3H-labeled ziprasidone. Blood, urine, and feces were collected at various intervals for determination of total radioactivity and metabolic profiles. Eleven days after the dose, 20.3 +/- 1% of the administered radioactivity was recovered in the urine and 66.3 +/- 4.8% in feces. The… CONTINUE READING


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