Metabolism and distribution of two highly potent and selective peptidomimetic inhibitors of matriptase

@article{Kotthaus2010MetabolismAD,
  title={Metabolism and distribution of two highly potent and selective peptidomimetic inhibitors of matriptase},
  author={J. Kotthaus and T. Steinmetzer and D. Schade and A. van de Locht and B. Clement},
  journal={Xenobiotica},
  year={2010},
  volume={40},
  pages={101 - 93}
}
Matriptase is a serine protease expressed by several types of cancer cells and it participates in tumour growth and progression through the activation of hepatocyte growth factor (HGF) and urokinase-type plasminogen activator (uPA). The metabolism of two potent and selective peptidomimetic inhibitors of matriptase (CJ-1737 and CJ-672) was examined in vitro with enzyme preparations (9000g supernatants, microsomes, and plasma) from dog, pig, rat, and human. It was found that both compounds… Expand
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