Corpus ID: 21401781

Metabolism and disposition of trifluoperazine in the rat. II. Kinetics after oral and intravenous administration in acutely and chronically treated animals.

@article{Schmalzing1977MetabolismAD,
  title={Metabolism and disposition of trifluoperazine in the rat. II. Kinetics after oral and intravenous administration in acutely and chronically treated animals.},
  author={G. Schmalzing},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1977},
  volume={5 2},
  pages={
          104-15
        }
}
  • G. Schmalzing
  • Published 1977
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological fate of chemicals
Male rats received 12.3 micronmol of trifluoperazine (CF3-PER) per kg orally or into the tail vein, and the kinetics of the drug and of its metabolites, 7-hydroxytrifluoperazine and desmethyltrifluoperazine, were followed from 0.5 to 8 hr after dosage. Brain, liver, lung, kidney, and plasma were analyzed by a thin-layer chromatographic method. Following iv injection, the levels of CF3-PER were much higher in brain, lung, kidney, and plasma obtained from the aorta than following oral… Expand
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