Metabolism and disposition of the 5-hydroxytryptamine uptake blocker sertraline in the rat and dog.

@article{Tremaine1989MetabolismAD,
  title={Metabolism and disposition of the 5-hydroxytryptamine uptake blocker sertraline in the rat and dog.},
  author={Larry M. Tremaine and William M. II Welch and Robert A. Ronfeld},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1989},
  volume={17 5},
  pages={542-50}
}
Sertaline [1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1- naphthalenamine] is a potent and selective inhibitor of neuronal serotonin uptake and is currently under development for the treatment of depression and of obesity. The drug is greater than 97% bound to plasma proteins, yet extensively distributes into tissues. The whole brain concentration of sertraline in the rat is more than 40-fold higher than that in plasma, and the volume of distribution is about 25 liters/kg in the… CONTINUE READING
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