Metabolism and disposition of novel des-fluoro quinolone garenoxacin in experimental animals and an interspecies scaling of pharmacokinetic parameters.

@article{Hayakawa2003MetabolismAD,
  title={Metabolism and disposition of novel des-fluoro quinolone garenoxacin in experimental animals and an interspecies scaling of pharmacokinetic parameters.},
  author={Hiroyoshi Hayakawa and Yoko Fukushima and Hiroshi Kato and Hiroyuki Fukumoto and Takumi Kadota and Hiroyuki Yamamoto and Hiroyuki Kuroiwa and Junko Nishigaki and Akira Tsuji},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2003},
  volume={31 11},
  pages={1409-18}
}
Garenoxacin is a novel quinolone that does not have a fluorine substituent at the C-6 position in the quinoline ring. Garenoxacin or 14C-garenoxacin was intravenously or orally administered to rats, dogs, and monkeys. Metabolic profiles and pharmacokinetic parameters were investigated focusing on the species differences and the allometric scaling of pharmacokinetic parameters. Garenoxacin was well absorbed following oral administration then underwent phase II metabolism in all species tested… CONTINUE READING
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Determinant of the distribution volume at steady state for novel quinolone pazufloxacin in rats

  • H Hayakawa, K Takagi, Y Fukushima, Y Kawamura, A Tsuji
  • J Pharm Pharmacol
  • 2002
1 Excerpt

The influence of BMS-284756 (T-3811ME) on metabolism of theophylline and activity of cytochrome P450 in human and rat microsomes

  • K Furuhata, H Fukuda, +6 authors H Narita
  • 2000
1 Excerpt

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