Metabolism and disposition of moxonidine in Fischer 344 rats.

@article{He2000MetabolismAD,
  title={Metabolism and disposition of moxonidine in Fischer 344 rats.},
  author={Minxia M. He and Trent L Abraham and Thomas J. Lindsay and Sylvia H. Chay and Boris A. Czeskis and Lisa Ann Shipley},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2000},
  volume={28 4},
  pages={
          446-59
        }
}
The metabolism and disposition of moxonidine (4-chloro-5-(imidazolidin-2-ylidenimino)-6-methoxy-2-methylp yrimidine ), a potent central-acting antihypertensive agent, were investigated in F344 rats. After an i.v. or oral administration of 0.3 mg/kg of [(14)C]moxonidine, the maximum plasma concentrations of moxonidine were determined to be 146.0 and 4.0 ng/ml, respectively, and the elimination half-lives were 0.9 and 1.1 h, respectively. The oral bioavailability of moxonidine was determined to… CONTINUE READING

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