Metabolism and disposition of [(14)C]1-nitronaphthalene in male Sprague-Dawley rats.

  title={Metabolism and disposition of [(14)C]1-nitronaphthalene in male Sprague-Dawley rats.},
  author={Jason S. Halladay and Jonathan Sauer and I. Glenn Sipes},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={27 12},
In rats and mice, 1-nitronaphthalene (1-NN) produces both lung and liver toxicity. Even though these toxicities have been reported, the metabolism and disposition of 1-NN have not been elucidated. Therefore, studies were performed to characterize its fate after i.p. and i.v. administration to male Sprague-Dawley rats. After i.p. administration of [(14)C]1-NN (100 mg/kg; 60 microCi/kg), 84% of the dose was eliminated in the urine and feces by 48 h. At 96 h, 60% of the dose was recovered in the… CONTINUE READING