Metabolism and disposition of gemcitabine, and oncolytic deoxycytidine analog, in mice, rats, and dogs.

@article{Shipley1992MetabolismAD,
  title={Metabolism and disposition of gemcitabine, and oncolytic deoxycytidine analog, in mice, rats, and dogs.},
  author={Lisa Ann Shipley and Theodore J Brown and J D Cornpropst and Michelle D. Hamilton and Wayne Daniels and H W Culp},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1992},
  volume={20 6},
  pages={
          849-55
        }
}
Gemcitabine, 2'-deoxy-2',2'-difluorocytidine, is a broad spectrum oncolytic compound with antitumor activity in solid tumor models. The pharmacokinetics, metabolism, and disposition of gemcitabine was examined in mice, rats, and dogs. All three species metabolize gemcitabine by deamination to the uracil metabolite. However, deamination in the mouse and dog was more extensive than in the rat. The mouse deaminated gemcitabine rapidly with the plasma concentration maximum of the uracil metabolite… CONTINUE READING

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