Metabolism and activation of N-nitrosodimethylamine by hamster and rat microsomes: comparative study with weanling and adult animals.

@article{Yoo1987MetabolismAA,
  title={Metabolism and activation of N-nitrosodimethylamine by hamster and rat microsomes: comparative study with weanling and adult animals.},
  author={Jee Soo Yoo and Shu Ning and Christopher J D Patten and Chung S Yang},
  journal={Cancer research},
  year={1987},
  volume={47 4},
  pages={992-8}
}
It has been reported that hamster liver preparations are more effective for the metabolic activation of N-nitrosodimethylamine (NDMA) to a mutagen than rat liver preparations. The enzymatic basis for this phenomenon, however, has not been clearly elucidated. The present study was undertaken to examine the enzymology of NDMA metabolism by different hepatic subcellular fractions prepared from hamsters and rats of two different ages, and to investigate the correlation between the metabolism and… CONTINUE READING