Metabolism and Renal Effects of Enflurane in Man

  title={Metabolism and Renal Effects of Enflurane in Man},
  author={Michael Cousins and L R Greenstein and Ben A. Hitt and Richard I. Mazze},
The metabolism and renal effects of enflurane were studied during and after anesthesia in ten surgical patients without renal disease; ten control patients received halothane. Enflurane was metabolized to inorganic fluoride with a mean peak serum level of 22.2 ± 2.8 µM four hours after anesthesia. Urinary inorganic and organic fluoride excretions were increased but oxalic acid excretion was not. suggesting that the latter is not an enflurane metabolite. Postanesthetic renal function, including… 

Effects of Renal Function on Serum Fluoride Level in Dogs During and After Enflurane Anesthesia

In dogs with no renal function, the increase rate and the peak of serum inorganic fluoride level were significantly higher than in dogs with renal function.

Fluoride Kinetics and Renal Function During Enflurane Anaesthesia

It is suggested that tubular reabsorption of fluoride is inversely related to tubular fluid pH and that fluoride is reabsorbed by non‐ionic diffusion.

Effects of Enflurane Anesthesia on the Function of Ischemically Damaged Kidneys

  • I. Wickström
  • Medicine, Chemistry
    Acta anaesthesiologica Scandinavica. Supplementum
  • 1979
The restitution of function of is chemically damaged kidneys was studied in two groups of dogs and the inorganir fluoride level achieved by enflurane anesthesia did not influence the restitution of renal function.

Metabolic Ability and Enflurane Defluorination in Surgical Patients

In the material as a whole, the enflurane dose was positively correlated with both post‐anaesthetic highest serum fluoride concentrations and the 24‐h fluoride excretion in urine, and there was a correlation between the 24-h post-anaesthetic urine pH as well as urine volume and fluoride excretions during that time.

Renal Function and Fluoride Formation and Excretion During Enflurane Anaesthesia

Central circulation, renal function, and fluoride formation and excretion were studied in nine patients during enflurane anaesthesia and surgery and there was no correlation between plasma fluoride levels and depression of any renal function variable.

Enflurane (Ethrane) anaesthesia in man. Metabolism and effects on biochemical and haematological variables.

It is concluded that renal dysfunction is unlikely to follow enflurane anaesthesia in patients with previously normal hepatic and renal function.

Effects of Prolonged Anesthesia with Enflurane or Halothane on Renal Function in Dogs

Renal function tests did not reveal any disturbance after enflurane anesthesia, and the two anesthetized groups did not differ in any of the parameters studied, except in serum inorganic fluoride levels.

Fluoride kinetics after enflurane anesthesia in healthy and anephric patients and in patients with poor renal function

Enflurane, a fluorinated methylethyl ether, is metabolized, in part, to inorganic fluoride, Methoxyflurane has similar metabolism, and cases of fluoride ion‐induced renal failure have been reported

Enflurane anesthesia and antipyrine metabolism

To evaluate the influence of enflurane anesthesia on the hepatic drug‐metabolizing capacity, antipyrine half‐life was measured in 18 surgical patients before surgery and on days 4 and 8 after anesthesia, and preanesthesia elimination rate of antipyrines did not indicate individual capacity to metabolize enFLurane.

Renal Fluoride Excretion During and After Enflurane Anaesthesia: Dependency on Spontaneous Urinary pH‐Variations

Renal function, fluoride formation and excretion were studied in patients during and after enflurane anaesthesia and surgery and there was a highly significant correlation between this increase in CF/CIn and the simultaneous rise in urinary pH between the two periods.