Metabolism and Disposition of Prescription Opioids: A Review.

  title={Metabolism and Disposition of Prescription Opioids: A Review.},
  author={Anne Depriest and Brandi L. Puet and Ashley C. Holt and Ali Roberts and Edward J. Cone},
  journal={Forensic science review},
  volume={27 2},
Opioid analgesics are commonly prescribed for acute and chronic pain, but are subject to abuse. Consequently, toxicology testing programs are frequently implemented for both forensic and clinical applications. Understanding opioid metabolism and disposition is essential for assessing risk of toxicity and, in some cases, providing additional information regarding risk of therapeutic failure. Opioids significantly metabolized by the cytochromeP450 (CYP450) enzyme system maybe subjectto drug-drug… CONTINUE READING