Metabolism and DNA binding of 1-nitropyrene and 1-nitrosopyrene in newborn mice.

Abstract

This study was carried out in order to evaluate possible mechanisms responsible for tumor induction by 1-nitropyrene and to provide insights on the higher tumorigenicity of 1-nitrosopyrene than 1-nitropyrene in newborn mouse liver. The "ground mouse" technique was used to follow the development of the metabolism of 1-nitropyrene and 1-nitrosopyrene in… (More)

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Cite this paper

@article{ElBayoumy1988MetabolismAD, title={Metabolism and DNA binding of 1-nitropyrene and 1-nitrosopyrene in newborn mice.}, author={Kamm El-Bayoumy and Guang-Hwa Shiue and Stephen S Hecht}, journal={Chemical research in toxicology}, year={1988}, volume={1 4}, pages={243-7} }